SNAP-8 is supplied as a catalogued research material in 10 mg.
SNAP-8 is used for the defined peptide acetyl octapeptide-3, but the name can also identify a branded aqueous cosmetic mixture. Registry values apply only to the pure Ac-EEMQRRAD-NH₂ peptide; powder or mixture status and excipients must be established by CoA and SDS [1–3].
Chemical properties and registry information
| Property | Value |
|---|---|
| Name and synonyms | Acetyl Octapeptide-3 |
| Material category | Cosmetic Peptide |
| Sequence | Ac-EEMQRRAD-NH2 |
| Molecular formula | C41H70N16O16S |
| Average molecular mass | 1075.2 g/mol |
| CAS Registry Number | 868844-74-0 |
| PubChem CID | CID 135688138 |
| Structural features | N-terminally acetylated and C-terminally amidated octapeptide. A fragment of the N-terminus of SNAP-25. |
| Appearance | White to off-white lyophilised powder |
| Solubility | Soluble in water. Reconstitute with sterile or bacteriostatic water. |
| Physical form | Catalogue vial; exact salt/counter-ion and excipients are batch-specific and must be verified in the CoA and SDS. |
Registry values apply only to the specific molecular entity, sequence, termini and material form. Batch records take precedence over family-level literature identifiers.
A synthetic peptide used in cosmetics to reduce the appearance of wrinkles. It is designed to mimic the N-terminal end of the SNAP-25 protein and competes for a position in the SNARE complex, which can modulate neurotransmitter release.
Research background and published evidence
Published research
Defensible contexts include peptide identity, LC–MS quantification, degradation studies and carefully controlled SNARE/SNAP-25-mimetic assay models. Mechanistic claims are often proprietary or extrapolated and should be treated as hypotheses rather than product specifications [2,3].
Current scientific understanding
Cosmetic-formulation studies, patents and data for acetyl hexapeptide-8 do not establish the identity or performance of pure SNAP-8 material. No topical or cosmetic use is permitted for this catalogue product.
Technical comparison
| Aspect | This catalogue material | Comparator |
|---|---|---|
| Identity | Acetyl octapeptide-3: Ac-EEMQRRAD-NH₂ | Acetyl hexapeptide-8: Ac-EEMQRR-NH₂ |
| Structural distinction | Contains two additional C-terminal residues, Ala-Asp | Terminates after the second Arg |
| Analytical implication | Confirm eight-residue sequence, N-acetylation and C-terminal amidation | Different intact mass and chromatographic reference |
Quality and testing
Quality information is batch- and presentation-specific. Use only the report linked to the exact size and lot. A report listed for another size, lot or similarly named material must not be treated as evidence for this product.
Chromatographic area purity, identity, net peptide or analyte content, water or counter-ion content, sterility, endotoxin and elemental impurities are different measurements. One result does not establish the others. Only tests supported by a visible, matching report should be regarded as available.
Laboratory handling and storage
Store and handle only under the conditions stated on the product label, batch CoA and SDS. Keep the container secured, correctly identified and protected from contamination. Do not infer storage, solvent compatibility or stability from a related compound.
Laboratory preparation, analytical-method selection, risk assessment, personal protective equipment and waste disposal should follow the applicable SDS and the institution’s approved procedures.
Regulatory and legal status
| Research-use notice | This material is supplied exclusively for laboratory research by qualified professionals and is not intended for human or veterinary use. Purchasers are responsible for compliance with applicable local requirements. |
Sources and references
- [1] PubChem. Acetyl octapeptide-3 compound record.
- [2] LC–MS/MS analysis of acetylated cosmetic peptides. BMC Chemistry (2020).
- [3] SNAP-25-derived peptide family patent.
Frequently Asked Questions
Do the CAS number and PubChem CID apply to every batch form?
Only when the exact sequence or structure, termini, conjugation, salt or counter-ion and hydration state match. The batch CoA and SDS govern; a related-compound identifier must not be substituted.
What does an analytical purity result mean?
It is method- and report-specific. For example, an HPLC area percentage is not automatically the same as identity, net content, sterility, endotoxin status or absence of elemental impurities.
How should the material be stored and handled?
Follow the exact label, batch CoA and SDS together with the institution’s risk assessment. Use only storage and stability information linked to the exact material form and batch.
