Semax
Price range: $21.00 through $41.00
Semax is supplied as a catalogued research material in 5 mg and 10 mg.
Semax is the seven-residue ACTH(4–7)-Pro-Gly-Pro sequence MEHFPGP. N-acetyl variants and acetate or TFA salts are separate analytical articles; the exact termini and counter-ion must be matched to the batch CoA [1–3].
Chemical properties and registry information
| Property | Value |
|---|---|
| Name and synonyms | Pro-Gly-Pro-ACTH (4-7), MEHFPGF, Met-Glu-His-Phe-Pro-Gly-Pro |
| Material category | Nootropic Peptide |
| Sequence | H-MEHFPGF-OH |
| Molecular formula | C37H51N9O10S |
| Average molecular mass | 813.93 g/mol |
| CAS Registry Number | 80714-61-0 |
| PubChem CID | CID 134791 |
| Structural features | Heptapeptide analogue of an ACTH fragment (ACTH 4-10) with a C-terminal Pro-Gly-Pro tripeptide extension. |
| Appearance | White to off-white lyophilised powder |
| Solubility | Soluble in bacteriostatic or sterile water. |
| Physical form | Catalogue vial; exact salt/counter-ion and excipients are batch-specific and must be verified in the CoA and SDS. |
Registry values apply only to the specific molecular entity, sequence, termini and material form. Batch records take precedence over family-level literature identifiers.
Semax is a heptapeptide drug developed in Russia, used as a nootropic and neuroprotective agent. It is an analog of the N-terminal fragment of adrenocorticotropic hormone (ACTH), ACTH (4-10), with a Pro-Gly-Pro C-terminal extension.
Research background and published evidence
Published research
Supported research contexts include peptide identity and stability, glial-cell gene-expression models and biophysical peptide–membrane or metal-coordination experiments. The literature does not establish one definitive direct receptor mechanism [2,3].
Current scientific understanding
Evidence is mainly cellular, animal and biophysical research. Results from a differently terminated, acetylated or salted Semax material cannot be transferred to this lot, and the literature does not establish human-use suitability.
Technical comparison
| Aspect | This catalogue material | Comparator |
|---|---|---|
| Identity | Semax: MEHFPGP, an ACTH-fragment-derived heptapeptide | Selank: TKPRPGP, a tuftsin-derived heptapeptide |
| Structural distinction | Met-Glu-His-Phe N-terminal region followed by PGP | Thr-Lys-Pro-Arg N-terminal region followed by PGP |
| Analytical implication | Use Semax-specific retention, sulfur-containing intact mass and impurity references | Shared PGP terminus does not establish interchangeability |
Quality and testing
Quality information is batch- and presentation-specific. Use only the report linked to the exact size and lot. A report listed for another size, lot or similarly named material must not be treated as evidence for this product.
Chromatographic area purity, identity, net peptide or analyte content, water or counter-ion content, sterility, endotoxin and elemental impurities are different measurements. One result does not establish the others. Only tests supported by a visible, matching report should be regarded as available.
Laboratory handling and storage
Store and handle only under the conditions stated on the product label, batch CoA and SDS. Keep the container secured, correctly identified and protected from contamination. Do not infer storage, solvent compatibility or stability from a related compound.
Laboratory preparation, analytical-method selection, risk assessment, personal protective equipment and waste disposal should follow the applicable SDS and the institution’s approved procedures.
Regulatory and legal status
| Research-use notice | This material is supplied exclusively for laboratory research by qualified professionals and is not intended for human or veterinary use. Purchasers are responsible for compliance with applicable local requirements. |
Sources and references
- [1] PubChem. Semax compound record.
- [2] Dolotov et al. Semax effects in rat glial-cell culture. Neuroscience Letters (2001).
- [3] Semax metal-coordination study. Journal of Inorganic Biochemistry (2016).
Frequently Asked Questions
Do the CAS number and PubChem CID apply to every batch form?
Only when the exact sequence or structure, termini, conjugation, salt or counter-ion and hydration state match. The batch CoA and SDS govern; a related-compound identifier must not be substituted.
What does an analytical purity result mean?
It is method- and report-specific. For example, an HPLC area percentage is not automatically the same as identity, net content, sterility, endotoxin status or absence of elemental impurities.
How should the material be stored and handled?
Follow the exact label, batch CoA and SDS together with the institution’s risk assessment. Use only storage and stability information linked to the exact material form and batch.
